Peptides studied for weight and blood sugar

Body weight, belly fat, blood sugar and insulin. 13 peptides, each with what researchers tested, its proof grade and its dose range.

"Studied for" means what researchers tested. It does not mean it works, or that it is safe or right for anyone. Check the proof grade: many of these were only tested in animals.

5-Amino-1MQ5A1MQ, 5-amino-1-methylquinolinium, NNMT inhibitorAnimal studies onlyWeight and blood sugarGrowth hormone and muscleFat loss and aging muscle. In mice it cut body weight and fat, and grew stronger muscle in old mice. Not a peptide.Common use: 50 mg to 100 mg per doseAICARacadesine, AICA-riboside, AICA ribosideHuman trialsWeight and blood sugarBlood sugar and how muscle uses fuel. In people it raised muscle sugar uptake and lowered liver sugar output. Not a peptide.Common use: 10 mg to 25 mg per doseAOD-9604AOD9604, hGH fragment 176-191 (Tyr-modified), Tyr-hGH 177-191Human trialsWeight and blood sugarHealing and recoveryFat loss, from a piece of growth hormone. Cut weight gain in obese rats and mice. Also tested on knee cartilage in rabbits.Common use: 250 mcg to 500 mcg per doseCagrilintideNN9838, AM833, long-acting amylin analogue (in CagriSema)Human trialsWeight and blood sugarWeight loss, alone and paired with semaglutide. Human trials showed lower body weight and HbA1c.Common use: 250 mcg to 4.5 mg per doseHGH Fragment 176-191AOD9604, AOD-9604, hGH fragment 177-191Animal studies onlyWeight and blood sugarHealing and recoveryFat loss, from the end piece of growth hormone. Cut weight and fat in obese rats and mice, and was tested on rabbit cartilage.Common use: 250 mcg to 500 mcg per doseRetatrutideLY3437943Human trialsWeight and blood sugarWeight loss and type 2 diabetes. In human trials it lowered body weight and HbA1c (3-month blood sugar).Common use: 1 mg to 12 mg per doseSemaglutideHuman trialsWeight and blood sugarHeart, blood vessels and energyType 2 diabetes, weight loss and heart risk. An approved drug. Human trials showed lower blood sugar, weight and fewer heart events.Common use: 250 mcg to 2.4 mg per doseTirzepatideLY3298176Human trialsWeight and blood sugarType 2 diabetes and weight loss. An approved drug. Human trials showed lower HbA1c and body weight.Common use: 2.5 mg to 15 mg per doseARA-290cibinetide, pHBSP, pyroglutamate helix B surface peptideHuman trialsHealing and recoveryWeight and blood sugarNerve pain and nerve damage, in sarcoidosis and diabetes. Human trials showed better nerve symptoms.Common use: 1 mg to 4 mg per doseIGF-1mecasermin, Increlex, rhIGF-I, insulin-like growth factor 1Human trialsGrowth hormone and muscleWeight and blood sugarGrowth and blood sugar. An approved drug for children who lack IGF-1. Human trials also tested it in diabetes.Common use: See schedule per doseMOTS-cAnimal studies onlyAging and longevityWeight and blood sugarMetabolism and exercise capacity. In mice it prevented weight gain on a fatty diet and improved running in old mice.Common use: 5 mg per dosePancragenKEDW, Lys-Glu-Asp-Trp-NH2, pancrageneAnimal studies onlySingle-organ bioregulatorsWeight and blood sugarThe pancreas and blood sugar. Lowered blood sugar in older people with diabetes and in monkeys.Common use: 10 mg per doseTesamorelinTH9507Human trialsGrowth hormone and muscleWeight and blood sugarBelly fat in people with HIV. An approved drug. It raises growth hormone and IGF-1 and cut deep belly fat in human trials.Common use: 1 mg to 2 mg per dose

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